Endocrine Abstracts

Introduction: Endoglin is a transmembrane auxiliary receptor for transforming growth factor-β (TGF-β) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or insulin sensitivity has been unexplored.Material and methods: Heterozygous deficient mice (HZ) were fed standard chow or high fat diet during 16 weeks. Blood glucose levels were measured after ...

Objective: To develop a specific questionnaire to evaluate the satisfaction of diabetic patients with the use of glucometers and evaluate their psychometric properties (feasibility, reliability, and validity).Material and methods: Two stages: i) questionnaire development: a set of 53 items was constructed after a bibliographic review. A panel of six experts and 50 patients concluded a 25-item version of the questionnaire (dimensions: satisfaction, inconv...

Introduction: Traumatic brain injury (TBI) is considered a rare cause of pituitary dysfunction. Recently, some retrospective studies demonstrated that TBI-mediated hypopituitarism is more frequent than previously known. However, its prevalence and natural history are still unclear.Objectives: To evaluate the prevalence of hypopituitarism 1 year after TBI and the association between the seriousness of the traumatism and the pituitary deficits.<p class...

Morbid obesity is associated with a decreased life expectancy and a myriad of serious medical problems. The Roux-en-Y gastric bypass (RYGBP) is the most effective procedure for the treatment of these patients, but it can be responsible of early and late complications. The aim of this prospective study was to evaluate the rate of visceral protein malnutrition (VPM) in morbid obese (MO) patients two years after laparoscopic RYGBP. Albumin (Alb), prealbumin (Prealb), transferrin ...

Introduction: Diabetic retinopathy (DR) is the most common microvascular complication in patients with type 1 diabetes (T1D), and the role of lipids in the development of this complication is still controversial. In this study we have analyzed the association between lipid levels at onset and during the follow-up and the subsequent development of DR.Methods: The cohort consists of 1132 patients with T1D who were diagnosed in Navarra between 1/1/1990 and ...

Premature Ovarian Insufficiency (POI) is defined as impairement of ovarian function in women under 40 years, with a incidence between 1-4% in women of reproductive age. Among the major identified causes of Premature Ovarian Insufficiency, genetic factors related with X-chromosome are widely described. However, autosome defects are less common found and are related generally with genetic mutations instead of structural abnormalities of them. Thefor, we report a relevant case of...

Introduction: Various thyroid imaging reporting and data systems (TIRADS) have been proposed in recent years, such as the EU-TIRADS proposed by the European Thyroid Association (ETA). These classification systems intend to estimate the malignancy risk of thyroid nodules, however they are very much based on suspicious ultrasound (US) features typical of papillary thyroid cancer. As such, follicular carcinomas may be reported as low suspicion nodules. Our work aims to evaluate t...

IntroductionExercise induces changes in the inflammatory profile that can comprehend changes during and immediately after exercise with long-term effects. This inflammatory profile could impact the cognitive function and so, the performance.ObjectivesCompare the inflammatory status from long duration and endurance exercises and correlate it with an immune and neuroendocrine genetic profile.<p class="abste...

Objectives: The use of thyroid hormones (TH) to treat obesity is not supported by evidence based on efficacy and safety, and this is reflected in recommendations of major international guidelines on hypothyroidism and obesity. We aimed to explore views about this practice among European thyroid specialists and their associations with respondent characteristics.Methods: Thyroid specialists from 28 countries were invited to participate in a questionnaire s...

Introduction: Immune checkpoint inhibitors (ICIs) are an effective treatment for advanced cancer, but they are not free from immune-related adverse events (irAEs). A common irAES is thyroid dysfunction (TD-irAEs) and, as such, may influence patient survival and response to ICIs.Objetives: The aim was to determine the incidence and characteristics of TD-irAEs among patients with advanced cancer treated with ICIs in a real-life setting and to investigate t...